Difluprednate 0.05% is used for postoperative inflammation; what is notable?

• A. Highest incidence of elevated intraocular pressure
• B. No risk of IOP elevation
• C. Causes systemic sedation
• D. Has antimicrobial properties

Answer: (A)

Difluprednate 0.05% is a very potent topical corticosteroid with excellent ocular penetration, which makes it highly effective for controlling postoperative inflammation. That same potency increases the likelihood of a steroid response, specifically elevating intraocular pressure in susceptible individuals. In practice, this means IOP monitoring is essential after starting this medication, especially in patients with glaucoma risk or a history of steroid-induced IOP rise. It does not have antimicrobial properties, and it does not cause systemic sedation. The standout or notable feature is the higher incidence of elevated IOP compared with other topical steroids.