Which prostaglandin agonist increases uveoscleral outflow?

• A. Bimatoprost 0.01%, 0.03%
• B. Latanoprost 0.005%
• C. Travoprost 0.004%
• D. Unoprostone 0.15%

Answer: (A)

Prostaglandin analogs lower intraocular pressure primarily by increasing aqueous humor outflow through the uveoscleral pathway. Among the options, the prostaglandin agonist most associated with boosting uveoscleral outflow is bimatoprost. It is formulated in 0.01% and 0.03% strengths and is well known for enhancing this nonconventional outflow route, contributing to its strong IOP-lowering effect. Latanoprost and travoprost also raise uveoscleral outflow, but unoprostone tends to affect the conventional trabecular outflow more than the uveoscleral pathway, making it a less fitting choice for this specific action.