Which prostaglandin analog is used to increase aqueous outflow in glaucoma management?

• A. Bimatoprost 0.01%, 0.03%
• B. Latanoprost 0.005%
• C. Travoprost 0.004%
• D. Unoprostone 0.15%

Answer: (A)

Prostaglandin analogs lower intraocular pressure by increasing aqueous humor outflow, mainly through the uveoscleral pathway. Among these options, bimatoprost is particularly effective and is commonly formulated at 0.01% and 0.03%, producing strong outflow enhancement and greater IOP reduction. It can influence both uveoscleral and, to some extent, trabecular outflow, which helps explain its potency. Latanoprost and travoprost also increase outflow but are considered somewhat less potent in practice, while unoprostone has a different activity profile and is used less commonly today. Therefore, the best choice for increasing aqueous outflow is bimatoprost.